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Figure 4 3.2 Dysregulation of inflammatory cytokinesthe core of excessive immune inflammatory responses Acute dysregulation of MPP typically occurs during the early phase of infection (12 weeks), characterized by excessive or dysregulated activation of the host innate immune system: (i) At the immune level, this primarily involves excessive cytokine release alongside overactivation of innate immune cells, initiating multifaceted proinflammatory cascades including NLRP

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