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doi: 10.1016/j.jaci.2017.07.008 131 BalashovDShcherbinaAMaschanMTrakhtmanPSkvortsovaYShelikhovaLet al

Overall, these results suggest that Mn overexposure triggers multiple programmed cell death pathways, including apoptosis and ferroptosis, through mitochondrial dysfunction, ER stress, and impaired redox balance

Certain red flags require prompt medical evaluation

[Updated 2025 Mar 5]

Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance

Distribution: The steady-state volume of distribution (Vdss) following administration of an intravenous dose of acetylcysteine was 0.47 liter/kg