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The immune system briefly becomes overwhelmed, creating a spike in inflammation

Physiol Behav 234:113387 Yoshimoto K, Komura S, Kawamura K (1992a) Occurrence in vivo of 5-hydroxytryptophol in the brain of rats treated with ethanol

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The successive supplementation of NAC to the granulomas from healthy subjects resulted in the statistically significant increase in the levels IFN- (Figure 2F)

This metabolic insult is compounded by ROS-induced endoplasmic reticulum stress, marked by the upregulation of UPR components like CHOP and GRP78, which further promotes hepatocyte apoptosis and inflammatory activation (Zhang et al., 2022)