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Selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts

Importantly, testicular IGF-1 exerts its beneficial role by binding with its respective receptor and simultaneously activating it, in an autocrine/paracrine manner, and hence contributes to the maintenance of normal male reproductive physiology
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K., Davey M., Cottrell J

Crit Rev Biochem Mol Biol 26(34):335375

Understanding this distinction helps reduce confusion and fear as treatment begins