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Confusion with Growth Hormone and Secretagogues Growth hormone: Acts systemically Alters IGF-1 signaling Can downregulate receptors over time Growth hormone secretagogues: Stimulate pituitary GH release Rely on receptor activation Can lose effectiveness if overstimulated AOD-9604 does neither

Developed using a mathematical model, the IDO metabolic trap hypothesis suggests that IDO2 damaging mutations are a genetic predisposition found in ME/CFS patients, which result in a dysfunctional IDO2 enzyme

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