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Epileptiform activity and EPSP-spike potentiation induced in rat hippocampal CA1 slices by repeated high-K(+): involvement of ionotropic glutamate receptors and Ca(2+)/calmodulin-dependent protein kinase II

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Also serum oxidized albumin, which reveals oxidative stress, is significantly higher in transplant patients from cadaver donors (53%) compared to that from living donors (36%)

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adverse or undesired effects Examples -- positive, beneficial drug interaction effects: Propranolol + hydralazine (reflex tachycardia (undesirable) caused by hypotensive hydralazine-mediated response is prevented by propranolol-mediated -adrenergic receptor blockade Opioid-induced respiratory depression may be counteracted by administration of the opioid receptor antagonist naloxone Adverse effects -- toxic reactions One drug may interact with another to impede absorption One drug may compete with another for the same plasma protein-binding sites One drug may affect metabolism of another by either enzyme induction or enzyme inhibition One drug may change the renal excretion rate of the other