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These symptoms usually fade as your body adjusts

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In the initial stages, these symptoms can be treated very effectively with the vitamin, however a persistent deficiency can cause irreversible damage to the nerves

Parathyroid hormone-(134) ameliorated knee osteoarthritis in rats via autophagy

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)