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In addition to these defining features, several histologic variants, such as gliosarcomas, giant-cell GBM, small-cell GBM, and epithelioid GBM, present distinct molecular and clinical implications

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It must be indicated that in earlier studies 10,11,17 the concentration of N-Hcy-Lys was less than 0.1 nmol/mL and in most cases could not be reliably determined in healthy individuals

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