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Tsukakoshi et al., 2018)
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The burden of significant pain in the cirrhosis population: Risk factors, analgesic use, and impact on health care utilization and clinical outcomes
L.RuprechtM.SchleiffE.et al (2016)
Alpha-lipoic acid (ALA), vitamin E, and acetyl-L-carnitine have all been studied in patients with DPN over the past ten years with variable results pertaining to their different antioxidant and anti-inflammatory effects on DPN [8, 12,13,14] Additionally, in preclinical models of diabetic neuropathy, natural supplements including curcumin, resveratrol, and melatonin as well as other antioxidants (Vitamins A, C, E and ALA) that target mitochondrial dysfunction have showed promising results [15,16,17,18] N-acetylcysteine (NAC) was previously shown to impact multiple pathogenetic pathways in DPN, making it a potential candidate for treatment
found CK-18 as a non-invasive biomarker for NASH by comparison of plasma samples from patients with biopsy proven NAFLD 22
