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In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect

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[DOI] [PubMed] [Google Scholar] 21.Forns X, Martinez-Bauer E, Feliu A, Garcia-Retortillo M, Martin M, Gay E, Navasa M, Sanchez-Tapias JM, Bruguera M, Rodes J

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