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Description
Activation of the ceramide pathway can engage destructive processes that can persist despite smoking cessation
A., Fahey, J
2010;298:C12091216
Pancreatic -cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
However, macrophages in more advanced plaques also have reduced lysosome function and trapping of free and esterified cholesterol within their lysosomes contributes to the overall sterol accumulation in the lesion (156-158)
Depleted SAM will decrease the GSH level and lead to a consequent suppression of antioxidant defense
