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Hyperhomocysteinemia may also contribute to the formation of tau protein and amyloid plaques within the brain, biomarkers of Alzheimers disease.35 Autism spectrum disorder is a bioneurological developmental disability that affects one in 36 children in the United States.37 Infants diagnosed with autism spectrum disorder have decreased plasma levels of methionine and cysteine and increased levels of homocysteine, compared with infants without autism

In such cases, supplementation becomes necessary

Indeed, an independent mechanism of the oxidant stress might be involved in the formation of the fibrous atherosclerotic lesion observed in hyperhomocysteinemia

This application may determine the reduction in systemic toxicity

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Glutathione deprivation converts GPX4-catalyzed peroxides to alcohols, leading to Cys deficiency, further inactivating GPX4 and promoting ferroptosis (Ursini and Maiorino, 2020)