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The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place

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Vitamin B12 is released into its free form in the stomach by hydrochloric acid and enzymes

In our previous works, a SNP (rs1941404) in the NNMT gene sequence was found significantly associated with impaired glucose tolerance and elevated fasting blood glucose [34]