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The extraction mixture content was 90% methanol and an internal standard for Kynurenine and tryptophan (Sigma-Aldrich, St

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Cui K., Xing G., Liu X., Wang Y

Glucose concentrations were determined by Oriental Yeast Co

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Upregulation of efflux transport at the BBB contributes to the barrier functions, while inhibition of efflux pump activity and downregulation of efflux transporter weaken the chemical defense of the brain and increase the brain entry of efflux pump substrate drugs [181]

37,38 Therefore, methotrexate could be a suitable candidate for drug repurposing strategies aimed at enhancing the efficacy of national and international cardiovascular prevention programmes