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Proteolytic digestions of Mpro revealed Cys300 as a primary target of glutathionylation, and experiments using a C300S Mpro mutant revealed that Cys300 is required for inhibition of activity upon Mpro glutathionylation

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Importantly, the selective nature of Ipamorelin ensures that cortisol levels remain unaffected, avoiding the counter-productive effects of elevated stress hormones on body composition