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Therefore, normal glomerular levels of HS are necessary for renal function in general and the control of glomerular permeability in particular (93, 108), and HS in small arterioles is necessary for the appropriate control of GFR (96) because it helps maintain the normal structure and function of blood vessels

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Specifically, there was an increase in the endoplasmic-reticulum-to-cytoplasm Zip7 mRNA and protein expression as well as phosphorylation, leading to elevated intracellular free zinc levels

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For future study, the top 150 genes with the highest node centrality, determined using principal component analysis within each module, were retrieved