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Crosstalk Between Metabolic Regulators and Metastatic Pathways Intrinsic Factors: Tumor-related Genes that Regulate Metabolic Pathways in Breast Cancer Metastatic Cascade TP53 TP53 mutations are very common in breast cancers, especially in triple-negative and HER2-positive subtypes (155)

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They emphasized that HO-1 functions as an oxidative agonist rather than a driver of ferroptosis, and that ferroptosis occurs only as a secondary event following severe oxidative damage (155)