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In macrophages and several other cell types, inflammatory mediators induce the transcriptional activation of the iNOS gene, resulting in accumulation of iNOS and increased synthesis of NO

Elghandour et al

doi: 10.1038/nm.3806

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Currently, dexrazoxane is the only FDA-approved option for preventing cardiotoxicity caused by anthracycline chemotherapy drugs

Here are the first things to focus on: Stop the activity immediately - If your child is playing sports or being physically active, have them sit out right away to prevent further injury