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Higher doses may saturate the receptor and trigger compensatory downregulation faster than lower doses

Among those who felt they needed to self-medicate, the main reasons given were to improve fatigue and to reduce brain fog and pins and needles

Here is a revised and more accurate explanation of the reasons a UK GP surgery might refuse to give a B12 injection a day earlier than scheduled, incorporating the points youve raised and providing a more scientifically grounded perspective: 1

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Of the 27 dogs: 22% had an elevated MMA value, indicative of vitamin B12 depletion at the tissue level