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However, the decrease in AMPK activation inhibited the phosphorylation of GFAT, which in turn promoted GFAT activity and ultimately upregulated the expression of O-GlcNAc transferase and O-GlcNAcase and led to the increased levels of global protein O-GlcNAc in H1299, HepG2 and MCF7 cells (61)
doi: 10.3390/biology10010035

Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction

RBM-007, an RNA aptamer designed to target fibroblast growth factor 2 (FGF2), is currently in Phase II clinical trials for treating neovascular AMD (nAMD)

Int J Cancer 138(1):195-205, 2016

Within this complex network, lymphatic endothelial cells (LECs) play a crucial role in regulating immune responses and influencing tumor progression and metastatic dissemination to lymph node and distant organs
