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Lasa JS, Zubiaurre I, Soifer LO

Once a compound shows consistent promise and an acceptable safety profile in non-clinical models, a pharmaceutical company would file an Investigational New Drug (IND) application

Glycolysis in red cells appears to be regulated simply by the energy needs of the cell, primarily for maintenance of ion gradients
LiYZhangMShengMZhangPChenZXingWet alTherapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia

NADPH is a reducing agent as well, required for the synthesis of lipids and nucleic acids and for the metabolism of neurotransmitters and aldehydes
