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In addition to the interplay of IRE1 with JNK, its RIDD activity is also associated with proapoptotic effects, e.g., through the cleavage of miR-17 and other miRNAs to relieve the suppression of TXNIP and CASP2

Older adults may have dysphagia

The sample size n = 5 mice for all experimental groups, except for the group ended at day 60 and comprised n = 4 mice

FTH neuron-specific knockout (FTH-KO) mice are more susceptible to ferroptosis after TBI, and the absence of FTH offsets the protective effect of melatonin on ferroptosis induced by TBI, 659 suggesting that melatonin plays a protective role at least in part by inhibiting FTH-mediated ferroptosis in neurons after TBI

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