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This is accompanied by a shift in macrophage populations, with a higher number of pro-inflammatory M1 macrophages and reduced anti-inflammatory M2 macrophages in Hunner lesions
Moreover, BPC 157 therapy generated from its distinctive healing effects in various tissues also functions as an eye drops therapy that heals perforating corneal ulcers in rats and rapidly regains corneal transparency (Figures 14, 15) (Masnec et al., 2015)

[DOI] [PubMed] [Google Scholar] Barr J.R., Pierce C.L., Smith J.R., Capacio B.R., Woolfitt A.R., Solano M.I., Wooten J.V., Lemire S.W., Thomas J.D., Ash D.H., Ashley D.L

Sci Rep 14 , 16059 (2024)

doi: 10.1016/j.bpj.2017.06.028

It is suggested that dysfunction between A production and clearance causes damaging accumulations of cellular A, coupled with hyperphosphorylation of neuronal tau protein resulting in neurofibrillary tangle formation [10,11])
