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2010;19(R1):R46-64

Grade 1 refers to mild affectation, with less than 10% of the body surface affected and minimal symptoms, such as mild itching, without interference with daily life

Both studies, albeit small and short in duration, showed improvement in heartburn symptoms with ranitidine and no adverse pregnancy outcomes

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Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo (75)