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doi: 10.1002/mco2.v4.4 [DOI] [PMC free article] [PubMed] [Google Scholar] 344

Designation: FOR RESEARCH USE ONLY

Collagen and extracellular matrix support GHK-Cu stimulates fibroblast proliferation and upregulates the expression of genes involved in synthesizing collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural proteins and proteoglycans that form the skins extracellular matrix

Some ideas: if ibuprofen isnt getting the job done, ask about a COX-2 inhibitor like Celebrex

Picro-Sirius red staining Rat pancreatic tissues were fixed in 4% paraformaldehyde (PFA) for 3 h and paraffin-embedded using a standard protocol