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doi: 10.1016/j.jpsychires.2006.07.013

The GCL enzyme is a heterodimer composed of a catalytic and a regulatory subunit

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HO-1 plays a protective role with anti-inflammatory, anti-tumor, anti-oxidation, anti-apoptosis, and other effects, by converting heme into antioxidant biliverdin, clearing ROS and inhibiting lipid peroxidation [54, 55]

Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]