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Miyazono Y, Gao F, Horie T (2009) Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats

In the cardiovascular system, senescent cells in the blood vessels promote arterial stiffness and endothelial dysfunction, increasing the risk of hypertension and atherosclerosis.25 In the brain, the buildup of senescent cells has been implicated in neurodegenerative diseases such as Alzheimers and Parkinsons, where they exacerbate neuroinflammation and neuronal loss.26 Similarly, in adipose tissue, the accumulation of senescent cells contributes to insulin resistance and the development of metabolic disorders such as type 2 diabetes.27 Senescent chondrocytes promote cartilage degradation and joint inflammation

Another example of lifelong use will be in people whove had all or part of their thyroid gland removed because of Graves disease or thyroid cancer

But does it work, or is it just another overhyped trend

Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy

Swanson, C
