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Disorders in purine metabolism, such as a deficiency in hypoxanthine phosphoribosyl-transferase and overactivity of phosphoribosyl pyrophosphate synthetase, lead to elevated UA levels [20]

doi: 10.1016/S0024-3205(03)00476-4

In the OLE, the omaveloxolone-omaveloxolone group referred to patients who started with omaveloxolone in the randomized controlled MOXIe Part 2, whereas the placebo-omaveloxolone group referred to those who started with placebo in MOXIe Part 2 and those from MOXIe Part 1 due to the long period off treatment

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