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It is worth noting that after lung injury, dipalmitoyl phosphatidylcholine (DPPC), as the main surfactant lipid component, is degraded into LysoPC through the phospholipase A2 activity of AEC2, further exacerbating the process of pulmonary fibrosis (Shi et al., 2024)

231 HIF-1 and HIF-2 are involved in regulating angiogenesis (e.g., VEGF) to couple osteogenesis, but HIF-1 primarily influences early osteoblast differentiation and may inhibit load-induced bone formation, whereas HIF-2 has a more pronounced role in regulating bone mass under specific conditions (e.g., in mature osteoblasts) and may exhibit functional complementarity or specific target gene regulation compared to HIF-1

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However, their presence and formation patterns vary depending on the cell type and the specific senescence-inducing stimuli