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Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Masashi W., Hatakeyama S

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These same principles could be extended to the design of inhaled peptide and protein therapies aimed at navigating or modulating the mucus barrier, particularly by integrating aerodynamic design with mucus-penetrating or mucus-protective features

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