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10.1016/s0891-5849(97)00463-2 124 QianQ.KassemK
Author contributions MLCS: Conceptualization, Writing original draft, Writing review & editing, Formal analysis, Investigation
The biggest change is an outward movement of the cytoplasmic part of the 5th and 6th transmembrane helix (TM5 and TM6)
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Summary and Perspectives The overall importance of HO is underlined by its large degree of evolutionary conservation in all kingdoms of life as it is expressed in prokaryotic and eukaryotic cells, bacteria, yeasts, protozoa, plants, invertebrate and vertebrate animals
