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with a meta-analysis suggesting anticonvulsants, which generally modulate glutamatergic, GABAergic and possibly other excitatory or inhibitory neuronal activity, have modest but significant efficacy in the treatment of alcohol dependence (Pani et al., 2014)

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Kaza N., Kohli L., Roth K.A

Rheumatology (Oxford) 56 , 362370 (2017)

The significance of these GABA/glutamate trends are unknown but may reflect compensatory immunomodulation, diet, microbiota, infection or unknown exogenous factors

10.3389/fimmu.2020.587913 278 YangL.GaoL.NickelT.YangJ.ZhouJ.GilbertsenA.et al (2017)

Moreover, they have provided the preclinical efficacy and safety data required for regulatory approval of several adjunctive therapies and local antimicrobials