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J Neurosci 26:334556, PMID: 16554485 Barger SW, Goodwin ME, Porter MM, Beggs ML (2007) Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation

Biochemistry 46 , 14321447 (2007)

Gene signatures and scoring Details of all gene signatures are provided in Supplementary Data

An attractive treatment approach is provided by prodrug therapy

Altogether, these results demonstrate that APR-246 induces GSH depletion which induces ferroptosis in AML cells irrespective of their TP53 mutational status, and that ferroptosis induction is the main mechanism of cell death after early exposure to APR-246

Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord
