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These reactions are under the control of several biotransformation enzymes which are sensitive to factors such as cofactor and conjugation substrate depletion and the inhibition (and sometimes the upregulation) of specific enzymes in the system

We conclude that

[PMC free article] [PubMed] [Google Scholar] 48.Vanegas H., Vazquez E., Tortorici V

These C-centered free radicals, R , react much faster, at diffusion-control rates, O 2 , leading to the rapid formation of peroxyl radicals ROO (reaction 2 in Figure 1)

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WangDDLiYBhupathirajuSNRosnerBASunQGiovannucciELet al
