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Fundamental definition and core mechanisms of oxidative stress Oxidative stress refers to a pathological state in which the rate of ROS and reactive nitrogen species (RNS) production exceeds the scavenging capacity of endogenous antioxidant systems, leading to oxidative damage of biomolecules (e.g., DNA, proteins, lipids) 7,13

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The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018

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