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Some users run it continuously for 6 months without reported issues, but this exceeds the controlled evidence base

A.BowerJ

Dryness and flaking: Kojic acid may disturb the lipid barrier, removing moisture from the skin's top layers
D.DangC
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS -activated cancer cells

Uwitonze, M.S