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10.3390/molecules25245932 134 SieberS.GrossenP.BussmannJ.CampbellF.KrosA.WitzigmannD.et al (2019)

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Initial findings from larger clinical trials using anti-IGF neutralizing antibodies were discouraging, as a Phase Ib/II study of xentuzumab, exemestane, and everolimus (mTOR inhibitor) combination therapy for advanced HR + breast cancer (NCT02123823) was discontinued early due to no change in PFS in the overall participant population [169]