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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

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Based on the TRP channel amino acid sequences and structural similarities they can be divided into six subsets: TRP canonical (TRPC), TRP vanilloid (TRPV), TRP melastatin (TRPM), TRPA, TRP mucolipin (TRPML), and TRP polycystic (TRPP) channels [85, 193]

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SCFAs were extracted by adding 1 mL of diethyl ether, followed by centrifugation at 2800 g for 5 minutes