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5 Initially, corresponding beneficial central influence on serotonin system was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed and markedly increased, 129 Porsolts test and chronic stress induced immobility reduced more than after imipramine administration while serotonin syndrome (irreversible monoamine oxidase [MAO]-inhibition+serotonin precursor as serotonin substrate) was fully counteracted

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Ann Neurol 24:446449 Malessa S, Leigh PN, Bertel O, Sluga E, Hornykiewicz O (1991) Amyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord