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This hormonal modulation involves changes in the activity of enzymes such as lysyl oxidase, which is crucial for forming stable collagen cross-links

Symptoms include: Peripheral neuropathy: Numbness, tingling, or burning sensations in the hands and feet Subacute combined degeneration of the spinal cord: Loss of balance, difficulty walking, weakness, and spasticity Cognitive impairment: Memory loss, confusion, and dementia Psychiatric symptoms: Depression, irritability, and personality changes Visual disturbances: Blurred or double vision Other Manifestations: Gastrointestinal symptoms: Sore tongue (glossitis), loss of appetite, nausea, vomiting, and diarrhea Dermatologic changes: Hyperpigmentation of the skin, vitiligo, and hair changes Note: The clinical presentation can vary depending on the severity and duration of the deficiency

ROS or RNS are formed during electron transfer reactions, by losing or accepting electron(s) (Halliwell and Gutteridge 2015)

[DOI] [PubMed] [Google Scholar] 75.Shepherd S., Gibson P

Epithalon , thymalin , and certain nootropic peptides are particularly sensitive