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The FDA added to the shot's packaging that it shouldn't be used longer than two years.Studies show that the shot could cause a loss of bone density, especially in teens who haven't gotten to their maximum bone mass

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That is what we know about it

the A-side buffer contained 100 M Lucifer yellow dye, in transport buffer (1.98 g/L glucose in 10 mM HEPES, 1 Hank's balanced salt solution, pH 7.4), and the B-side buffer was transport buffer at pH 7.4

The trial tested oral administration primarily, and no controlled study has tested subcutaneous injection in humans