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This provides a middle ground between purely systemic and directly local administration

Does it guarantee weight loss?+ No

In fact, some people do this when they need extra B12 but still want the broader benefits of the other B vitamins

Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]

ISBN 978-1-84603-407-7

But because of their potency and potential risks, they are controlled by laws: you must have a consultation and a prescription to get them, and they should be used by the intended patient according to the instructions