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Histology of the lesions revealed intense superficial edema with a moderate perivascular and interstitial inflammatory infiltrate formed of lymphocytes, histiocytes, and numerous eosinophils, occupying the full thickness of the dermis and infiltrating the subcutaneous adipose tissue

La molecola di carnitina viene quindi trasportata indietro nello spazio intermembranico dallo stesso cotrasportatore mentre l'acil-CoA grasso viene ossidato e utilizzato per la produzione di ATP

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This lack of complete separation is in line with earlier metabolomics studies in ASD and reflects both biological variability and the multifactorial nature of the condition

Complementary clinical and meta-analytic data consistently demonstrate systemic redox imbalance, including lower glutathione reserves, altered GSH/GSSG ratios, increased lipid peroxidation, and dysregulated NRF2 signaling, linking oxidative status to immune activation and synaptic dysfunction (James et al., 2004