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In rats, intraperitoneal administration of glutamine increased glycogen in the skeletal muscle [19]

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By contrast, folinic acid can yield 5,10-methyl-THF or 5-methyl-THF without requiring DHFR, making it particularly useful for counteracting the effects of chemotherapeutic agents (38,39)

Topical administration offers the benefit of limiting the systemic exposure

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Toxicity was also evaluated in SDO (synthetic dextrose minus tryptophan or leucine)