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CrossRef Efficacy and safety of lobeglitazone added to metformin and sitagliptin combination therapy in patients with type 2 diabetes: A 52week, multicentre, randomized, placebocontrolled, phase III clinical trial EunGyoung Hong, KyungWan Min, SungWan Chun, Choon Hee Chung, Seungjoon Oh, Chang Beom Lee, DongJun Kim, Hye Soon Kim, Ji Oh Mok, Tae Seo Sohn, Jeong Hyun Park, Sung Hee Choi, Sungrae Kim, Sang Soo Kim, Kyu Yeon Hur, Chong Hwa Kim, Young Min Cho, Byung Diabetes, Obesity and Metabolism.2025

Growing evidence indicates that targeting these metabolic dependencies may offer therapeutic benefit, whether through dietary approaches like the ketogenic diet, pharmacologic inhibition of glycolysis and glutaminolysis, or disruption of mitochondrial activity and hypoxia/angiogenesis pathways

However, multidimensional techniques have refined or complicated these classifications, including single-cell omics technologies (31)

Conte A, Lattante S, Zollino M, Marangi G, Luigetti M, Del Grande A, et al

For example, drugs such as rapamycin and metformin have been shown to inhibit the spread of senescent cells [306]

R., Briggs, W
