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There have been no additions of these peptides to the 503A bulk list, no guidance suggesting enforcement discretion, and no public statements signaling tolerance for routine injectable use of these unapproved drugs

2018 Jul 23;28(14):2302-2308.e3

Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, et al

doi: 10.1515/bchm3.1995.376.11.651

Advances in Nanocarriers for Anticancer Drugs Delivery

This is largely due to the unique biological and clinical characteristics of GB, including dynamic evaluation of the tumor, its highly heterogeneous tumor microenvironment, and poor drug penetration through BBB, as illustrated in Figure 3
