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2004;6(6):R713R722.

They help with conditions like muscle weakness, joint pain, and nerve damage

B12 injections provide energy and even help with deeper sleep

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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease

Standard research protocols generally use 500600 mcg daily, administered as a single morning dose or split into 250300 mcg twice daily