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doi: 10.1039/C9AN02440A

In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

Maruyama J, Miller JM, Ulfendahl M (2008) Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness

470 During cell development, different cell cycles exhibit varying sensitivities to radiation, Specifically, the G2/M phase exhibits the highest sensitivity to radiation, whereas the S phase demonstrates radioresistance

These side effects are not menacing and do not require medical attention

A typical treatment plan involves precision injections every three to four months