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Description
Upon breaching the intestinal barrier, LPS binds to Toll-like receptor 4 (TLR4), which not only activates the NF-B pathway to drive the release of pro-inflammatory cytokines but also directly suppresses the transcription factor Nrf2-mediated antioxidant pathway, thereby exacerbating both inflammation and ROS accumulation (Zhang et al., 2022
26 This is likely due to the absence of the common -grasp domain found in Type I-, I-, and II enzymes
G.BarisicM
doi: 10.1002/eji.202049114 51 KapralovAAYangQDarHHTyurinaYYAnthonymuthuTSKimRet al
JAMA 2007
Neurochem Res 34(1):5565
