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Nuclear gene regulation: Overexpression of PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) can activate the NRF1/TFAM pathway, driving the expression of genes related to mitochondrial biogenesis (such as COX5B, ATP5F1), and enhancing mitochondrial DNA (mtDNA) replication and respiratory chain complex assembly (99101)

11 The exact mechanism of statin-induced autoimmune hepatitis/immune-mediated DILI is not clear

Male infertility is often accompanied by low sperm count and the production of reactive oxygen species (ROS) that exert stress on the sperm cells, producing infertility

However, this method suffers from a disadvantage associated with a difficulty of application thereof to a practical process due to a high cost of (S)-3-hydroxy-gamma-butyrolactone as the starting material

Multiple studies have shown the positive effects of probiotics in reducing TMA levels and alleviating CVDs, with the probiotics including Enterobacter aerogenes , Lactobacillus rhamnosus , Saccharomyces boulardii , and Bifidobacterium animalis subsp